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3D-Bioprinting: how is it helping us understand collagen remodelling?

Dr. Leila Mostaço-Guidolin

Assistant Professor, Department of Systems and Computer Engineering, Carleton University

January 30, 2020 18:00 - 19:00

Mackenzie Building Room 4359, Carleton University

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Paid parking available on campus

abstract

Imaging modalities capable of characterizing cells and tissues help us to understand the progression of diseases, detecting lesions with a high risk for acute events, and even providing information that can be applied to the development of new drugs or therapies. Multimodal nonlinear optical microscopy (NLOM) is a powerful tool that can be used for label-free visualization of key extracellular molecules, such as collagen and elastin, which are involved in detrimental remodeling of several tissues. In this presentation, I will share a story of how image analysis methods can help us to track changes happening in respiratory diseases. I will also show how 3D-bioprinting can be used in basic research, as a tool to build simplified models of complex biological systems, such as the extracellular matrix in tissue.

biography

Dr. Mostaço-Guidolin obtained her doctorate from the Biomedical Engineering program at the University of Manitoba, working in a close collaboration with the National Research Council in Winnipeg. She developed image analysis methods to characterize cardiovascular diseases. After completing her graduate work, she moved to Vancouver to undertake a postdoctoral position at the University of British Columbia, at the Center for Heart and Lung Innovation, working on the application of imaging modalities for respiratory research and the development of 3D in-vitro models. At Carleton University, she will be establishing a 3D-bioprinting/imaging lab to study changes associated with fibrosis and extracellular matrix remodelling in diseases.